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Excitatory Amino Acid Receptor Changes Induced by Neonatal Bilateral Ventral Hippocampus Lesion in Rats PDF
By:Zimbul Albo Angelus
Published on 1997 by

|Bilateral excitotoxic lesions of the ventral hippocampus in neonatal rats result in hyperlocomotion induced by dopamine agonists, and hyperresponsiveness to stress in postpubertal animals. A cortical maldevelopment has been suggested to explain the behavioral changes observed but direct evidence is lacking to support this assumption. We studied possible alterations in excitatory amino acids receptor levels in this animal model of schizophrenia. Ventral hippocampal lesion at postnatal day 7 (PD7) induced significantly increased locomotor activity after a D-amphetamine injection (1mg/kg) in PD56 and 6 month-old (PD 180) rats but not PD35 ones. In addition, behavioral deficits were observed in postpubertal rats in the radial arm maze test. By using a $ lbrack sp{125} rm I rbrack$-MK-801 receptor binding autoradiography protocol, neonatal ventral-hippocampal-lesioned rats depicted significant postpubertal increased levels of N-methyl-D-aspartate (NMDA) receptors in frontal cortical regions at ages PD56 and 6 month, but not prepubertally at PD35. $ lbrack sp{3} rm H rbrack$-AMPA receptor binding levels were also found increased in 6-month old rats, while no significant changes in $ lbrack sp3 rm H rbrack$-kainate receptor binding levels were found at any of the ages studied. Finally, metabotropic glutamate receptor levels measured by $ lbrack sp3 rm H rbrack$-glutamate binding were decreased in PD56 and PD180. Taken together our results suggest that cortical glutamate abnormalities observed in hippocampal-lesioned rats are of enduring nature and may underlie some of the behavioral changes observed in these animals.| --

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